Cocaine - Metabolism and excretion, detect in urine
Cocaine is extensively metabolized, primarily in the liver, with only about 1% excreted unchanged in the urine. The metabolism is dominated by hydrolytic ester cleavage, so the eliminated metabolites consist mostly of benzoylecgonine, the major metabolite, and in lesser amounts ecgonine methyl ester and ecgonine.
If taken with alcohol, cocaine combines with the ethanol in the liver to form cocaethylene, which is both more euphorigenic and has higher cardiovascular toxicity than cocaine by itself.
Cocaine metabolites are detectable in urine for up to four days after cocaine is used. Benzoylecgonine can be detected in urine within four hours after cocaine inhalation and remains detectable in concentrations greater than 1000 ng/ml for as long as 48 hours. Detection in hair is possible in regular users until the sections of hair grown during use are cut or fall out.
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Cocaine - Anesthetic, lidocaine, benzocaine
Cocaine in its purest form is a white, pearly product. Cocaine appearing in powder form is a salt, typically cocaine hydrochloride (CAS 53-21-4). Black market cocaine is frequently adulterated or cut with various powdery fillers to increase its surface area; the substances most commonly used in this process are baking soda; sugars, such as lactose, dextrose, inositol, and mannitol; and local anesthetics, such as lidocaine or benzocaine, which mimic or add to cocaine's numbing effect on mucous membranes. Cocaine may also be "cut" with other stimulants such as methamphetamine. Adulterated cocaine is often a white, off-white or pinkish powder. Novacaine, a dental anesthetic and benzocaine (an ingredient used in Anbesol and other non-prescription oral anesthetics) are related to cocaine and can both cause a person to test positive for it even though they are not illegal drugs.
The color of "crack" cocaine depends upon several factors including the origin of the cocaine used, the method of preparation with ammonia or sodium bicarbonate and the presence of impurities, but will generally range from white to a yellowish creme to a light brown. Its texture will also depend on the adulterants, origin and processing of the powdered cocaine, and the method of converting the base; but will range from a crumbly texture, sometimes extremely oily, to a hard, almost crystalline nature.
Fast COC Detox Kit for People Under 200 Lbs
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Cocaine - Prohibition, abuse
By the turn of the twentieth century, the addictive properties of cocaine had become clear to many, and the problem of cocaine abuse began to capture public attention in the United States. The dangers of cocaine abuse became part of a moral panic that was tied to the dominant racial and social anxieties of the day. In 1903, the American Journal of Pharmacy stressed that most cocaine abusers were bohemians, gamblers, high- and low-class prostitutes, night porters, bell boys, burglars, racketeers, pimps, and casual laborers. In 1914, Dr. Christopher Koch of Pennsylvania's State Pharmacy Board made the racial innuendo explicit, testifying that, Most of the attacks upon the white women of the South are the direct result of a cocaine-crazed Negro brain. Mass media created an epidemic of cocaine use among African Americans in the Southern United States to play upon racial prejudices of the era, though there is little evidence that such an epidemic actually took place. In the same year, the Harrison Narcotics Tax Act outlawed the use of cocaine in the United States. This law incorrectly referred to cocaine as a narcotic, and the misclassification passed into popular culture. As stated above, cocaine is a stimulant, not a narcotic.
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