Detox, short for detoxification, in general is the removal of toxic substances from the body. It is one of the functions of the liver and kidneys, but can also be achieved artificially by techniques such as dialysis and (in a very limited number of cases) chelation therapy.

Other less mainstream methods for eliminating toxic substances from the body include the modification of the diet and addition of certain herbs and rituals such as colonic irrigation, juice fasting and sweat lodges. All these methods claim to assist the body's natural detoxification process.

Specific meanings of detoxification or detox:

1. A form of drug rehabilitation, used to treat alcoholism or other drug addiction. The process involves abstinence to clear the drug from the body, accompanied by social and environmental support during the associated physiological and psychological changes. A non-drug method for detox from drugs or alcohol is acupuncture detoxification.

2. A class of diets whose underlying assumption is that the body accumulates toxins that must be purged, especially after unhealthy periods such as over-eating during festivals. Toxins, in this case, refer to toxic substances - often of undefined nature - from foods, the environment and the body's own wastes. "Detox diet" is a common phrase, as is "I'm on a detox". See detox diet.

3. Forms of complementary medicine that claim to remove such toxins from the body: for instance, by herbal, electrical or electromagnetic treatments. As the definition of toxins in this and the previous context has little scientific basis, the validity of such techniques is questionable. There is no evidence for such accumulation; the liver and kidneys automatically detoxify and excrete many toxic materials, including metabolic wastes. Under this theory if toxins are too rapidly released without being safely eliminated (such as burning fat that stores toxins) they can pollute the body causing malaise.

4. A process by which a substance is made less toxic.

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The following chart gives approximate drug detection periods for each substance by test type. The detection period ranges depend on amount and frequency of use, metabolic rate, body mass, age, overall health, and urine pH. For ease of use, the detection times of metabolites have been incorporated into each parent drug. For example, heroin and cocaine can only be detected for a few hours after use, but their metabolites can be detected for several days in urine. In this type of situation, we will report the (longer) detection times of the metabolites.

NOTE 1: Oral fluid or saliva testing results for the most part mimic that of blood. The only exception is THC. Oral fluid will likely detect THC from ingestion up to a maximum period of 18-24 hours.

NOTE 2: Urine can not detect current drug use. It takes approximately 6-8 hrs. post-consumption for drug to be metabolized and excreted in urine. Similarly, hair requires two weeks, and sweat, seven days.

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Short-term effects of methamphetamine

Drug testing in the United States basically began in the late 1980's with the testing of certain federal employees and specified DOT regulated occupations. Drug testing guidelines and processes, in these areas exclusively, are established and regulated (by the Substance Abuse and Mental Health Services Administration, formerly under the direction of the National Institute on Drug Abuse or NIDA) require that companies who use professional drivers, specified safety sensitive transportation and/or oil and gas related occupations, and certain federal employers, test them for the presence of certain drugs. These test classes were established decades ago, and include five specific drug groups. They do not account for current drug usage patterns. For example, the tests do not include "synthetic opiates", such as oxycodone, oxymorphone, hydrocodone, hydromorphone, etc., compounds that are highly abused in America:

• Cannabinoids (marijuana, hashish)
• Cocaine (cocaine, crack, benzoylecognine)
• Amphetamines (amphetamines, methamphetamine, speed)
• Opiates (heroin, opium, codeine, morphine)
• Phencyclidine (PCP)

While SAMHSA/NIDA guidelines only allow labs to report quantitative results for the "NIDA-5" on their official NIDA tests, many drug testing labs and on-site tests also offer a wider or "more appropriate" set of drug screens which are more reflective of current drug abuse patterns. As noted above, these tests include synthetic pain killers such as Oxycodone, Oxymorphone, Hydrocodone, Hydromorphone, benzodiazepines (Valium, Xanax, Klonopin, Restoril) and barbiturates in other drug panels (a "panel" is a predetermined list of tests to run). The confirmation test (usually GCMS) can tell the difference between methamphetamine and ecstasy, and in the absence of detectable amounts of methamphetamine in the sample, the lab will either report the sample as negative or report it as positive for MDMA. What the lab reports to the client depends upon whether MDMA was included in the panel as something to be tested for.

Gamma-hydroxy-butyrate (GHB) was not routinely tested for in the early 1990s, but due to increasing use, some labs have added it as an optional test. GHB is rare in pre-employment screening, but is commonly checked for in suspected cases of drug overdose, date rape, and post-mortem toxicology tests. Ketamine (Special K) may or may not be tested for, depending upon the preferences of the entity paying for the test, though testing for it is uncommon. In general, the greater the number of drugs tested for, the higher the price of the test, so many employers stick to the NIDA 5 for financial reasons.

Other drugs, such as meperidine (Demerol), fentanyl, propoxyphene, and methadone are not commonly tested for in most pre-employment situations. These drugs are more likely to be included in tests for certain demographic groups (such as healthcare workers, drug rehab patients, etc.)

Hallucinogens other than cannabis and PCP, such as mushrooms (psilocybin), LSD, and peyote (mescaline) are rarely tested for.

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Methamphetamine drug testing

Dope may refer to:

• Dope, slang for a stupid person
• Dope, street slang for something good, nice or "cool".
• Dope, slang for heroin, methamphetamine, or Cannabis, depending on region.
• Dope, in aeronautics, slang for a varnish used to waterproof, strengthen, etc. (So called because solvent fumes from the varnish affected the workers applying it.)
• Dope (band), an industrial rock band based in Chicago
• Dope, slang for information
• Dope, (Data On Personal Equipment) windage and elevation settings for a particular rifle and ammo

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Cocaine is extensively metabolized, primarily in the liver, with only about 1% excreted unchanged in the urine. The metabolism is dominated by hydrolytic ester cleavage, so the eliminated metabolites consist mostly of benzoylecgonine, the major metabolite, and in lesser amounts ecgonine methyl ester and ecgonine.

If taken with alcohol, cocaine combines with the ethanol in the liver to form cocaethylene, which is both more euphorigenic and has higher cardiovascular toxicity than cocaine by itself.

Cocaine metabolites are detectable in urine for up to four days after cocaine is used. Benzoylecgonine can be detected in urine within four hours after cocaine inhalation and remains detectable in concentrations greater than 1000 ng/ml for as long as 48 hours. Detection in hair is possible in regular users until the sections of hair grown during use are cut or fall out.

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Cocaine in its purest form is a white, pearly product. Cocaine appearing in powder form is a salt, typically cocaine hydrochloride (CAS 53-21-4). Black market cocaine is frequently adulterated or cut with various powdery fillers to increase its surface area; the substances most commonly used in this process are baking soda; sugars, such as lactose, dextrose, inositol, and mannitol; and local anesthetics, such as lidocaine or benzocaine, which mimic or add to cocaine's numbing effect on mucous membranes. Cocaine may also be "cut" with other stimulants such as methamphetamine. Adulterated cocaine is often a white, off-white or pinkish powder. Novacaine, a dental anesthetic and benzocaine (an ingredient used in Anbesol and other non-prescription oral anesthetics) are related to cocaine and can both cause a person to test positive for it even though they are not illegal drugs.

The color of "crack" cocaine depends upon several factors including the origin of the cocaine used, the method of preparation with ammonia or sodium bicarbonate and the presence of impurities, but will generally range from white to a yellowish creme to a light brown. Its texture will also depend on the adulterants, origin and processing of the powdered cocaine, and the method of converting the base; but will range from a crumbly texture, sometimes extremely oily, to a hard, almost crystalline nature.

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By the turn of the twentieth century, the addictive properties of cocaine had become clear to many, and the problem of cocaine abuse began to capture public attention in the United States. The dangers of cocaine abuse became part of a moral panic that was tied to the dominant racial and social anxieties of the day. In 1903, the American Journal of Pharmacy stressed that most cocaine abusers were bohemians, gamblers, high- and low-class prostitutes, night porters, bell boys, burglars, racketeers, pimps, and casual laborers. In 1914, Dr. Christopher Koch of Pennsylvania's State Pharmacy Board made the racial innuendo explicit, testifying that, Most of the attacks upon the white women of the South are the direct result of a cocaine-crazed Negro brain. Mass media created an epidemic of cocaine use among African Americans in the Southern United States to play upon racial prejudices of the era, though there is little evidence that such an epidemic actually took place. In the same year, the Harrison Narcotics Tax Act outlawed the use of cocaine in the United States. This law incorrectly referred to cocaine as a narcotic, and the misclassification passed into popular culture. As stated above, cocaine is a stimulant, not a narcotic.

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Cocaine is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. It is a stimulant of the central nervous system and an appetite suppressant, creating what has been described as a euphoric sense of happiness and increased energy. Though most often used recreationally for this effect, cocaine is also a topical anesthetic used in eye, throat, and nose surgery. Cocaine can be addictive and can cause physical and psychological dependence. Its possession, cultivation, and distribution is illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of the world. The name comes from the name of the coca plant plus the alkaloid suffix -ine.

The stimulating qualities of the coca leaf were -known to the ancient peoples of Peru and other Pre-Columbian South American societies. In modern Western countries, cocaine has been a feature of the counterculture for well-over a century; there is a long-list of prominent intellectuals, artists, and musicians who have used the drug - names ranging from Sir Arthur Conan Doyle and Sigmund Freud to United States President Ulysses S. Grant. For many decades cocaine was a key ingredient in Coca-Cola. Today, although illegal in virtually all countries, cocaine remains popular in a wide-variety of social and personal settings.

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